The optimal number of donor biopsy sites to evaluate liver histology for transplantation

The optimal number of donor biopsy sites to evaluate liver histology for transplantation.

Macrovesicular steatosis (MaS), fibrosis, and inflammation have been associated with poor graft function after liver transplantation. We evaluated histological variation in livers to determine the optimal number of biopsies to estimate pathological characteristics in livers for transplantation. Specimens from autopsies performed during 3 months in 16- to 70-years-olds without known liver diseas...

Evaluation of the donor liver for living donor liver transplantation.

Key Points 1. Accurate assessment of the donor liver is an important component of the living donor liver evaluation and is critical to ensure a successful outcome for both donor and recipient. 2. Liver biochemistry tests, viral hepatitis serological tests, tests to exclude chronic liver disease, and volumetric computed tomographic or magnetic resonance (MR) imaging of the liver are performed ro...

The Optimal Timing of Living-Donor Liver Transplantation

L donors are a significant and increasing source of livers for transplantation, mainly because of the insufficient supply of cadaveric organs. We consider the problem of optimally timing a living-donor liver transplant to maximize the patient’s total reward, such as quality-adjusted life expectancy. We formulate a Markov decision process (MDP) model in which the state of the process is describe...

Outcomes of living donor liver transplantation for acute liver failure: the adult-to-adult living donor liver transplantation cohort study.

For acute liver failure (ALF), living donor liver transplantation (LDLT) may reduce waiting time and provide better timing compared to deceased donor liver transplantation (DDLT). However, there are concerns that a partial graft would result in reduced survival of critically ill LDLT recipients and that the rapid evolution of ALF would lead to selection of inappropriate donors. We report outcom...

Liver Biopsy After Liver Transplantation